Manchester City are already 14 points adrift of league leaders Liverpool in their quest to win a third successive Premier League title thus making the Arsenal game a must-win for them but they might be without two key players for the match billed to take place at the Emirates Stadium.
Key Manchester City players Ederson Moraes and David Silva are doubtful for the Arsenal game later on Sunday.
The two players missed the midweek win over Croatian side Dinamo Zagreb in the Champions League.
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Brazilian international Gabriel Jesus scored a hattrick as Manchester City beat their hosts 4-1 to complete their Group C campaign with an emphatic win.
England teen sensation Phil Foden got the other goal for the Premier League champions, while the lone strike for the home team came from Spanish international Dani Olmo.
Ederson Moraes is the first choice goalkeeper at Manchester City and he missed the Dinamo Zagreb match as a result of illness, while Spanish international David Silva got a knock last weekend in thr league during the Manchester Derby clash at home to Manchester United and missed the Champions League game on Wednesday night as a result.