Both teams are in Group H with Dutch champions Ajax Amsterdam and Spanish La Liga side Valencia.
Chelsea go into the game on the back of the poor run of one win in five matches in all competitions including three defeats from their last four Premier League games.
Only a win will guarantee a spot in the last 16 for Chelsea and they are massive favourites to achieve that against Lille regarded as the worst team in their group.
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Chelsea manager Frank Lampard would be hoping that the home game against Lille at Stamford Bridge on Tuesday night will give his players the opportunity to bounce back from the Everton.
Lampard and his Chelsea players suffered a 3-1 away defeat to Everton on Saturday lunchtime in a Week 16 clash.
Fikayo Tomori missed the Everton game with a knock and he’s not expected to feature against Lille with Andreas Christensen set to continue in his absence.
Likely Chelsea XI (4-3-3): Kepa Arrizabalaga; Reece James, Andreas Christensen, Kurt Zouma, Cesar Azpilicueta; Jorginho, Mateo Kovacic, Mason Mount; Tammy Abraham, Christian Pulisic and Willian.