Premier League giants Chelsea have suffered a triple injury blow for their Champions League meeting with Valencia on Tuesday night.
The two teams meet at Stamford Bridge in a Group H clash.
Antonio Rudiger, Ruben Loftus-Cheek and Emerson Palmieri missed training earlier on Monday and they will all miss the Valencia game.
Antonio Rudiger has battled with a knee injury for the better part of the last six months and has made his return at the weekend.
He played in the Premier League clash between Wolves and Chelsea on Saturday.
Chelsea won the game 5-2 to secure their second win of the new Premier League season.
Tammy Abraham was the star of the show after the Nigerian-born England international scored three goals to take his league tally to seven goals in the last three games.
Fikayo Tomori and Mason Mount were also on target for Chelsea during the Wolves game.
Emerson Palmieri sustained an injury during the international break in the colors of the Italian national team.
He missed the Wolves game at the weekend as a result of the aforementioned injury and the left-back will also sit out the Valencia game.
England international midfielder Ruben Loftus-Cheek will also miss the Champions League clash.