Premier League table-toppers Liverpool start the defense of their Champions League title with a trip to Italy to face Napoli who is under the guidance of their manager, Carlo Ancelotti.
The two teams are no stranger to each other after meeting at the same stage in the last campaign.
They both won the home leg by a lone strike in the Champions League group stage last season.
Napoli and Liverpool faced off during the first game of the group stage last season and it ended in a 1-0 for the Italians with Lorenzo Insigne giving the lone strike.
Insigne scored the only goal of the game in the stroke of full-time.
Liverpool won the reverse leg by the same scoreline courtesy the goal from Sadio Mane but theirs was more important as the victory took them to the round of 16.
Liverpool then went on to overcome German Bundesliga giants Bayern Munich in the last 16, Portuguese giants FC Porto in the quarterfinals, Spanish champions Barcelona in the last four and fellow Premier League team in the final to win the title.
Possible Liverpool XI vs Napoli: Adrian; Trent Alexandre-Arnold, Joel Matip, Virgil Van Dijk, Andy Robertson; Georginio Wijnaldum, Fabinho, Jordan Henderson; Sadio Mane, Roberto Firmino and Mohamed Salah.