The Red Devils have had a very good festive period after winning their last two games and a win over the Gunners will make it three victories in a row.
Manchester United have been able to close the gap on Chelsea in fourth place to just four points as a result of the last two Premier League games which ended in victory.
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Ahead of the game, Manchester United manager Ole Gunnar Solskjaer hinted that star player Paul Pogba will return to his squad to face the Gunners having been rested for the away trip to Burnley at the weekend.
Pogba has been restricted to just eight appearances for Manchester United this season after a hard time with an ankle problem.
He is likely to be the only change from the starting XI for the Burnley game which ended in a 2-0 win for Manchester United.
Expected Manchester United XI vs Arsenal: David De Gea, Aaron Wan-Bissaka, Harry Maguire, Victor Lindelof, Luke Shaw; Nemanja Matic, Fred, Paul Pogba; Anthony Martial, Daniel James and Marcus Rashford.