Arsenal midfielder Aaron Ramsey has withdrawn from the Wales squad ahead of their UEFA Nations League meeting with Home nation rivals, the Republic of Ireland.
Ramsey, 27, will miss the game at the Aviva Stadium in Dublin due to family reasons.
The former Cardiff City star had earlier featured for the team in Thursday’s international friendly game with former world champions Spain.
He captained the Welsh team on Thursday but could not prevent his side from suffering a 4-1 defeat to Luis Enrique and his players.
His withdrawal from the squad was confirmed by the Football Association of Wales (FAW) via a tweet on Monday morning.
He becomes the second high profile player to pull out of the Republic of Ireland game after Real Madrid forward Gareth Bale.
Wales manager Ryan Giggs has promoted Swansea City winger David James from the U21s as a replacement for him.
Aaron Ramsey earlier missed Arsenal’s Europa League away clash at Qarabag to be with his partner who’s pregnant with twins.
Wales manager Ryan Giggs and his players have their work cut out against their rivals.
They would be without their best players, Gareth Bale and Aaron Ramsey, for the game in Dublin.
A win would be enough to take Wales to the top of their group ahead of leaders Denmark.